| First Author | Heymer J | Year | 1999 |
| Journal | Mech Dev | Volume | 88 |
| Issue | 2 | Pages | 173-81 |
| PubMed ID | 10534616 | Mgi Jnum | J:58673 |
| Mgi Id | MGI:1349335 | Doi | 10.1016/s0925-4773(99)00186-0 |
| Citation | Heymer J, et al. (1999) Syndactyly of Ft/+ mice correlates with an imbalance in bmp4 and fgf8 expression. Mech Dev 88(2):173-81 |
| abstractText | The most obvious phenotype of Ft/+ mice is a syndactyly of fore limbs characterised by a fusion of the tips of digits 1 to 4. The tempospatial expression of genes involved in limb development revealed that patterning of Ft/+ limb buds is not affected by the mutation. However, an upregulation of Bmp4 in the anterior-distal region of the limb bud at d12.0 of embryonic development is accompanied by a loss of Fgf8 expression in the distal part of the AER. Downstream target genes of Bmp action such as Msx1 and 2 are upregulated. This induction of the signalling cascade indicates ectopic expression of functional Bmp4. Nevertheless, analysis of physical parameters of bones from adult mice revealed a reduction of the bone mass of the autopod. The data suggest a negative effect of Bmp4 on Fgf8 expression and a positive influence on the induction of bone elements. |
