| First Author | Gong SG | Year | 2001 |
| Journal | Cleft Palate Craniofac J | Volume | 38 |
| Issue | 6 | Pages | 622-8 |
| PubMed ID | 11681996 | Mgi Jnum | J:106502 |
| Mgi Id | MGI:3618669 | Doi | 10.1597/1545-1569_2001_038_0622_pditm_2.0.co_2 |
| Citation | Gong SG, et al. (2001) Palatal development in Twirler mice. Cleft Palate Craniofac J 38(6):622-8 |
| abstractText | OBJECTIVE: The development of the secondary palate of Twirler (Tw) mice was characterized, and a quantitative coronal plane evaluation of the width and length of the craniofacial regions of homozygous mutant embryos was conducted. RESULTS AND CONCLUSIONS: The secondary palatal shelves were retarded in growth and the timing of elevation from a vertical to horizontal position. The homozygous Tw embryos, when compared with their wild-type littermates, also had a significantly wider midface. It is not surprising, therefore, that the short palatal shelves in a wide midface resulted in cleftings of the secondary palate observed in all homozygous Tw mice. These findings are consistent with similar studies in humans and other murine models. |
