| First Author | Tian F | Year | 2016 |
| Journal | FEBS J | Volume | 283 |
| Issue | 8 | Pages | 1465-74 |
| PubMed ID | 26881904 | Mgi Jnum | J:252338 |
| Mgi Id | MGI:6092993 | Doi | 10.1111/febs.13684 |
| Citation | Tian F, et al. (2016) Pulmonary resident neutrophils regulate the production of GM-CSF and alveolar macrophages. FEBS J 283(8):1465-74 |
| abstractText | Alveolar macrophages exist in the lung airspaces, and their differentiation and function are considerably regulated by the microenvironment. In this study, we examine the important role of resident neutrophil/IL-23/granulocyte/macrophage colony-stimulating factor (GM-CSF) axis in the development and preferential phenotype of alveolar macrophages under physiological conditions. Using CD18-deficient (CD18(-/-) ) mice, we show a correlation between increased granulopoiesis and enhanced alveolar macrophage development in an IL-23- and GM-CSF-dependent manner. The apoptotic neutrophils could inhibit the secretion of IL-23 from alveolar macrophages, which is important for the production of GM-CSF, and depletion of neutrophils disrupted the regulation of IL-23 and GM-CSF. This study reveals a mechanism for the regulation of the local alveolar macrophage population and function by neutrophil apoptosis in the circulatory system. |
