| First Author | Chavakis E | Year | 2005 |
| Journal | J Exp Med | Volume | 201 |
| Issue | 1 | Pages | 63-72 |
| PubMed ID | 15623573 | Mgi Jnum | J:95265 |
| Mgi Id | MGI:3525762 | Doi | 10.1084/jem.20041402 |
| Citation | Chavakis E, et al. (2005) Role of beta2-integrins for homing and neovascularization capacity of endothelial progenitor cells. J Exp Med 201(1):63-72 |
| abstractText | The mechanisms of homing of endothelial progenitor cells (EPCs) to sites of ischemia are unclear. Here, we demonstrate that ex vivo-expanded EPCs as well as murine hematopoietic Sca-1+/Lin- progenitor cells express beta2-integrins, which mediate the adhesion of EPCs to endothelial cell monolayers and their chemokine-induced transendothelial migration in vitro. In a murine model of hind limb ischemia, Sca-1+/Lin- hematopoietic progenitor cells from beta2-integrin-deficient mice are less capable of homing to sites of ischemia and of improving neovascularization. Preactivation of the beta2-integrins expressed on EPCs by activating antibodies augments the EPC-induced neovascularization in vivo. These results provide evidence for a novel function of beta2-integrins in postnatal vasculogenesis. |
