| First Author | Liebergall SR | Year | 2020 |
| Journal | Mol Cell Biol | Volume | 40 |
| Issue | 2 | PubMed ID | 31658997 |
| Mgi Jnum | J:291984 | Mgi Id | MGI:6447441 |
| Doi | 10.1128/MCB.00364-19 | Citation | Liebergall SR, et al. (2020) Inflammation Triggers Liver X Receptor-Dependent Lipogenesis. Mol Cell Biol 40(2) |
| abstractText | Immune cell function can be modulated by changes in lipid metabolism. Our studies indicate that cholesterol and fatty acid synthesis increases in macrophages between 12 and 18 h after the activation of Toll-like receptors with proinflammatory stimuli and that the upregulation of lipogenesis may contribute to the resolution of inflammation. The inflammation-dependent increase in lipogenesis requires the induction of the liver X receptors, members of the nuclear receptor superfamily of transcription factors, by type I interferons in response to inflammatory signals. Instead of the well-established role for liver X receptors in stimulating cholesterol efflux, we demonstrate that liver X receptors are necessary for the proper resumption of cholesterol synthesis in response to inflammatory signals. Thus, liver X receptors function as bidirectional regulators of cholesterol homeostasis, driving efflux when cholesterol levels are high and facilitating synthesis in response to inflammatory signals. Liver X receptor activity is also required for the proper shutdown of a subset of type I interferon-stimulated genes as inflammation subsides, placing the receptors in a negative-feedback loop that may contribute to the resolution of the inflammatory response. |
