| First Author | Maruyama J | Year | 2022 |
| Journal | PLoS Pathog | Volume | 18 |
| Issue | 5 | Pages | e1010557 |
| PubMed ID | 35605008 | Mgi Jnum | J:328525 |
| Mgi Id | MGI:7285573 | Doi | 10.1371/journal.ppat.1010557 |
| Citation | Maruyama J, et al. (2022) CD4 T-cell depletion prevents Lassa fever associated hearing loss in the mouse model. PLoS Pathog 18(5):e1010557 |
| abstractText | Lassa virus (LASV) is the causative agent of Lassa fever (LF), which presents as a lethal hemorrhagic disease in severe cases. LASV-induced hearing loss in survivors is a huge socioeconomic burden, however, the mechanism(s) leading to hearing loss is unknown. In this study, we evaluate in a mouse LF model the auditory function using auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAE) to determine the mechanisms underlying LASV-induced hearing loss. In the process, we pioneered measures of ABR and DPOAE tests in rodents in biosafety level 4 (BSL-4) facilities. Our T cell depletion studies demonstrated that CD4 T-cells play an important role in LASV-induced hearing loss, while CD8 T-cells are critical for the pathogenicity in the acute phase of LASV infection. Results presented in this study may help to develop future countermeasures against acute disease and LASV-induced hearing loss. |
