| First Author | Wenzek C | Year | 2022 |
| Journal | iScience | Volume | 25 |
| Issue | 12 | Pages | 105540 |
| PubMed ID | 36437873 | Mgi Jnum | J:331693 |
| Mgi Id | MGI:7397845 | Doi | 10.1016/j.isci.2022.105540 |
| Citation | Wenzek C, et al. (2022) CD47 restricts antiviral function of alveolar macrophages during influenza virus infection. iScience 25(12):105540 |
| abstractText | CD47 is an ubiquitously expressed surface molecule with significant impact on immune responses. However, its role for antiviral immunity is not fully understood. Here, we revealed that the expression of CD47 on immune cells seemed to disturb the antiviral immune response as CD47-deficient mice (CD47(-/-)) showed an augmented clearance of influenza A virus (IAV). Specifically, we have shown that enhanced viral clearance is mediated by alveolar macrophages (aMcapital EF, Cyrillic). Although aMcapital EF, Cyrillic displayed upregulation of CD47 expression during IAV infection in wildtype mice, depletion of aMcapital EF, Cyrillic in CD47(-/-) mice during IAV infection reversed the augmented viral clearance. We have also demonstrated that CD47 restricts hemoglobin (HB) expression in aMcapital EF, Cyrillic after IAV and severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, with HB showing antiviral properties by enhancing the IFN-beta response. Our study showed a negative role for CD47 during antiviral immune responses in the lung by confining HB expression in aMcapital EF, Cyrillic. |
