| Primary Identifier | MGI:1862004 | Allele Type | Chemically induced (ENU) |
| Gene | Zic2 | Inheritance Mode | Dominant |
| Strain of Origin | BALB/cAnNCrl | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The mutation in the kumba mouse was identified as a T to A transversion at coding nucleotide 1105. The resulting missense mutation (p.C369S), is located in the fourth zinc finger domain and the altered cysteine is a canonical residue required to to chelate zinc. Mutations in equivalent residues of other zinc finger proteins predict that this substitution would abolish the function of the zinc finger domain. |
