| First Author | Li Z | Year | 2006 |
| Journal | Blood | Volume | 107 |
| Issue | 1 | Pages | 106-10 |
| PubMed ID | 16174759 | Mgi Jnum | J:125796 |
| Mgi Id | MGI:3759935 | Doi | 10.1182/blood-2005-05-1955 |
| Citation | Li Z, et al. (2006) Runx1 function in hematopoiesis is required in cells that express Tek. Blood 107(1):106-10 |
| abstractText | Runx1 expression marks the putative hemogenic endothelium between embryonic days (E) 8.5 to 11.5 of mouse gestation and is required for the formation of intra-aortic hematopoietic clusters, leading to the hypothesis that Runx1 is required for the transition from endothelial to hematopoietic cell. To address this hypothesis, we ablated the Runx1 gene by Cre-recombinase-mediated excision, with Cre expression under the control of the Tek promoter and enhancer. Most embryos died between E12.5 and E13.5 with a phenotype almost identical to Runx1 deficiency. We conclude that Runx1 function in establishing definitive hematopoiesis is required in a Tek+ cell. |
