| First Author | Dietrich MO | Year | 2012 |
| Journal | Nat Neurosci | Volume | 15 |
| Issue | 8 | Pages | 1108-10 |
| PubMed ID | 22729177 | Mgi Jnum | J:191603 |
| Mgi Id | MGI:5462154 | Doi | 10.1038/nn.3147 |
| Citation | Dietrich MO, et al. (2012) AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors. Nat Neurosci 15(8):1108-10 |
| abstractText | It is not known whether behaviors unrelated to feeding are affected by hypothalamic regulators of hunger. We found that impairment of Agouti-related protein (AgRP) circuitry by either Sirt1 knockdown in AgRP-expressing neurons or early postnatal ablation of these neurons increased exploratory behavior and enhanced responses to cocaine. In AgRP circuit-impaired mice, ventral tegmental dopamine neurons exhibited enhanced spike timing-dependent long-term potentiation, altered amplitude of miniature postsynaptic currents and elevated dopamine in basal forebrain. Thus, AgRP neurons determine the set point of the reward circuitry and associated behaviors. |
