| First Author | Vitaterna MH | Year | 1994 |
| Journal | Science | Volume | 264 |
| Issue | 5159 | Pages | 719-25 |
| PubMed ID | 8171325 | Mgi Jnum | J:18005 |
| Mgi Id | MGI:66027 | Doi | 10.1126/science.8171325 |
| Citation | Vitaterna MH, et al. (1994) Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 264(5159):719-25 |
| abstractText | In a search for genes that regulate circadian rhythms in mammals, the progeny of mice treated with N-ethyl-N-nitrosourea (ENU) were screened for circadian clock mutations. A semidominant mutation, Clock, that lengthens circadian period and abolishes persistence of rhythmicity was identified. Clock segregated as a single gene that mapped to the midportion of mouse chromosome 5, a region syntenic to human chromosome 4. The power of ENU mutagenesis combined with the ability to clone murine genes by map position provides a generally applicable approach to study complex behavior in mammals. |
