| First Author | Challet E | Year | 2000 |
| Journal | Brain Res | Volume | 859 |
| Issue | 2 | Pages | 398-403 |
| PubMed ID | 10719095 | Mgi Jnum | J:61117 |
| Mgi Id | MGI:1354463 | Doi | 10.1016/s0006-8993(00)02040-0 |
| Citation | Challet E, et al. (2000) Nonphotic phase-shifting in clock mutant mice. Brain Res 859(2):398-403 |
| abstractText | Nonphotic phase-shifting was studied in mice bearing the Clock mutation. First, free-running mice heterozygous for Clock and wild-type mice were induced to become active through a 4-h confinement to a novel running over 3 days. Second, mice exposed to light-dark cycle received daily hypocaloric food during 2 weeks, before being transferred to constant darkness and fed ad libitum. Behavioral activation during the mid-subjective day induced 40-min phase advances in the locomotor activity rhythm of wild-type mice, whereas it produced 50-min phase delays in the circadian behavior of Clock/+ mice. Calorie restriction phase-advanced by 80 min the locomotor activity rhythm in wild-type mice, but not in Clock/+ mice. Therefore, the response of the Clock/+ mice to nonphotic phase shifting differs from that of wild-type mice. |
