Primary Identifier | MGI:1861635 | Allele Type | Chemically induced (ENU) |
Gene | Crygs | Inheritance Mode | Semidominant |
Strain of Origin | (101 x C3H)F1 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | A single base pair mutation (T to C) in exon 2 replaces Phe with Ser at amino acid position 9 of the protein. The mutant protein shows a concentration dependent decrease in solubility and a loss of secondary structure at near-physiological temperatures. |