| Primary Identifier | MGI:1861640 | Allele Type | Transgenic |
| Gene | Fancl | Inheritance Mode | Recessive |
| Strain of Origin | (CBA/J x C57BL/6J)F2 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | This mutation was identified as a transgene insertion that also deletes approximately 150 kb of genomic sequence at the insertion site. This deletion removes exons 4-14 of Fancl and also removes exons 2-11 of a neighboring gene Vrk2. The transgene contains a fragment of goat DNA. A transgene expressing Vrk2 that was introduced into homozygous mice failed to rescue the phenotype, suggesting that the deletion of Fancl was solely responsible for the phenotype seen in these mice. |
