| First Author | Morrison A | Year | 1999 |
| Journal | Mech Dev | Volume | 84 |
| Issue | 1-2 | Pages | 169-72 |
| PubMed ID | 10473135 | Mgi Jnum | J:56415 |
| Mgi Id | MGI:1340935 | Doi | 10.1016/s0925-4773(99)00066-0 |
| Citation | Morrison A, et al. (1999) Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear. Mech Dev 84(1-2):169-72 |
| abstractText | The Notch signalling pathway is thought to play a key part in controlling the production of sensory hair cells in the vertebrate inner ear via lateral inhibition; but there is disagreement as to which Notch ligands are expressed in hair cells as they develop. We show, using a mouse Delta1:LacZ knock-in as a reporter, that nascent hair cells, but not their neighbours, express Delta1. Expression of Serrate1 (Jagged1), meanwhile becomes restricted to the supporting cells of each sensory patch. Delta1 is also expressed: (a) at early stages, at the site of otic neurogenesis; and (b) in scattered cells of the endolymphatic sac, as is Serrate1. |
