| First Author | Hazenbos WL | Year | 1996 |
| Journal | Immunity | Volume | 5 |
| Issue | 2 | Pages | 181-8 |
| PubMed ID | 8769481 | Mgi Jnum | J:35057 |
| Mgi Id | MGI:82508 | Doi | 10.1016/s1074-7613(00)80494-x |
| Citation | Hazenbos WL, et al. (1996) Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. Immunity 5(2):181-8 |
| abstractText | The family of receptors for IgG (Fc gamma R) plays an essential role in antibody-mediated effector functions of the immune system. However, the specific contribution of each of the Fc gamma R classes to in vivo immune reactions is still unclear. Here, we demonstrate that mice deficient for the ligand-binding alpha chain of Fc gamma RIII lack NK cell-mediated antibody-dependent cytotoxicity and phagocytosis of IgG1-coated particles by macrophages. Strikingly, these mice lack IgG-mediated mast cell degranulation, are resistant to IgG-dependent passive cutaneous anaphylaxis, and exhibit an impaired Arthus reaction. These results indicate a prominent role for Fc gamma RIII in inflammatory and anaphylactic responses, making this receptor a potential target in immunotherapy. |
