| First Author | van Es JH | Year | 2012 |
| Journal | Nat Cell Biol | Volume | 14 |
| Issue | 10 | Pages | 1099-1104 |
| PubMed ID | 23000963 | Mgi Jnum | J:193937 |
| Mgi Id | MGI:5469940 | Doi | 10.1038/ncb2581 |
| Citation | van Es JH, et al. (2012) Dll1+ secretory progenitor cells revert to stem cells upon crypt damage. Nat Cell Biol 14(10):1099-104 |
| abstractText | Lgr5+ intestinal stem cells generate enterocytes and secretory cells. Secretory lineage commitment requires Notch silencing. The Notch ligand Dll1 is expressed by a subset of immediate stem cell daughters. Lineage tracing in Dll1(GFP-ires-CreERT2) knock-in mice reveals that single Dll1(high) cells generate small, short-lived clones containing all four secretory cell types. Lineage specification thus occurs in immediate stem cell daughters through Notch lateral inhibition. Cultured Dll1(high) cells form long-lived organoids (mini-guts) on brief Wnt3A exposure. When Dll1(high) cells are genetically marked before tissue damage, stem cell tracing events occur. Thus, secretory progenitors exhibit plasticity by regaining stemness on damage. |
