| First Author | Mihaylova MM | Year | 2018 |
| Journal | Cell Stem Cell | Volume | 22 |
| Issue | 5 | Pages | 769-778.e4 |
| PubMed ID | 29727683 | Mgi Jnum | J:271497 |
| Mgi Id | MGI:6278061 | Doi | 10.1016/j.stem.2018.04.001 |
| Citation | Mihaylova MM, et al. (2018) Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging. Cell Stem Cell 22(5):769-778.e4 |
| abstractText | Diet has a profound effect on tissue regeneration in diverse organisms, and low caloric states such as intermittent fasting have beneficial effects on organismal health and age-associated loss of tissue function. The role of adult stem and progenitor cells in responding to short-term fasting and whether such responses improve regeneration are not well studied. Here we show that a 24 hr fast augments intestinal stem cell (ISC) function in young and aged mice by inducing a fatty acid oxidation (FAO) program and that pharmacological activation of this program mimics many effects of fasting. Acute genetic disruption of Cpt1a, the rate-limiting enzyme in FAO, abrogates ISC-enhancing effects of fasting, but long-term Cpt1a deletion decreases ISC numbers and function, implicating a role for FAO in ISC maintenance. These findings highlight a role for FAO in mediating pro-regenerative effects of fasting in intestinal biology, and they may represent a viable strategy for enhancing intestinal regeneration. |
