| First Author | He F | Year | 2017 |
| Journal | Development | Volume | 144 |
| Issue | 21 | Pages | 4026-4036 |
| PubMed ID | 28947535 | Mgi Jnum | J:245766 |
| Mgi Id | MGI:5915646 | Doi | 10.1242/dev.151068 |
| Citation | He F, et al. (2017) Dysregulated PDGFRalpha signaling alters coronal suture morphogenesis and leads to craniosynostosis through endochondral ossification. Development 144(21):4026-4036 |
| abstractText | Craniosynostosis is a prevalent human birth defect characterized by premature fusion of calvarial bones. In this study, we show that tight regulation of endogenous PDGFRalpha activity is required for normal calvarium development in the mouse and that dysregulated PDGFRalpha activity causes craniosynostosis. Constitutive activation of PDGFRalpha leads to expansion of cartilage underlying the coronal sutures, which contribute to suture closure through endochondral ossification, in a process regulated in part by PI3K/AKT signaling. Our results thus identify a novel mechanism underlying calvarial development in craniosynostosis. |
