| First Author | Dogbevia GK | Year | 2015 |
| Journal | Front Cell Neurosci | Volume | 9 |
| Pages | 142 | PubMed ID | 25954155 |
| Mgi Jnum | J:254000 | Mgi Id | MGI:6101568 |
| Doi | 10.3389/fncel.2015.00142 | Citation | Dogbevia GK, et al. (2015) Inducible and combinatorial gene manipulation in mouse brain. Front Cell Neurosci 9:142 |
| abstractText | We have deployed recombinant adeno-associated viruses equipped with tetracycline-controlled genetic switches to manipulate gene expression in mouse brain. Here, we show a combinatorial genetic approach for inducible, cell type-specific gene expression and Cre/loxP mediated gene recombination in different brain regions. Our chemical-genetic approach will help to investigate ''when'', ''where'', and ''how'' gene(s) control neuronal circuit dynamics, and organize, for example, sensory signal processing, learning and memory, and behavior. |
