| First Author | Yajima I | Year | 2006 |
| Journal | Genesis | Volume | 44 |
| Issue | 1 | Pages | 34-43 |
| PubMed ID | 16419042 | Mgi Jnum | J:105276 |
| Mgi Id | MGI:3614603 | Doi | 10.1002/gene.20182 |
| Citation | Yajima I, et al. (2006) Spatiotemporal gene control by the Cre-ERT2 system in melanocytes. Genesis 44(1):34-43 |
| abstractText | The organ-specific and temporal control of gene activation/inactivation is a key issue in the understanding of protein function during normal and pathological development and during oncogenesis. We generated transgenic mice bearing a tamoxifen-dependent Cre recombinase (Tyr::Cre-ERT2) gene expressed under the control of a 6.1 kb murine tyrosinase promoter in order to facilitate targeted spatiotemporally controlled somatic recombination in melanoblasts/melanocytes. Cre-ERT2 production was detected in tissues containing melanocytes. After tamoxifen induction at various times during embryogenesis and adulthood in a Cre-responsive reporter mouse strain, genetic recombination was detected in the melanoblasts and melanocytes of the skin. Thus, the Tyr::Cre-ERT2 transgenic mice provides a valuable tool for following this cell lineage and for investigating gene function in melanocyte development and transformation. |
