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Publication : Mouse prostate epithelial luminal cells lineage originate in the basal layer where the primitive stem/early progenitor cells reside: implications for identifying prostate cancer stem cells.

First Author  Zhou J Year  2013
Journal  Biomed Res Int Volume  2013
Pages  913179 PubMed ID  23819124
Mgi Jnum  J:232002 Mgi Id  MGI:5775710
Doi  10.1155/2013/913179 Citation  Zhou J, et al. (2013) Mouse prostate epithelial luminal cells lineage originate in the basal layer where the primitive stem/early progenitor cells reside: implications for identifying prostate cancer stem cells. Biomed Res Int 2013:913179
abstractText  Prostate stem cells are thought to be responsible for generation of all prostate epithelial cells and for tissue maintenance. The lineage relationship between basal and luminal cells in the prostate is not well clarified. We developed a mouse model to trace cell fate and a mouse model with a slowly cycling cell label to provide insight into this question. The results obtained indicate that putative mouse prostate stem cells are likely to reside in the basal layer.
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