| First Author | Miwa H | Year | 2018 |
| Journal | Development | Volume | 145 |
| Issue | 2 | PubMed ID | 29378823 |
| Mgi Jnum | J:270956 | Mgi Id | MGI:6278721 |
| Doi | 10.1242/dev.155879 | Citation | Miwa H, et al. (2018) Tracing the destiny of mesenchymal stem cells from embryo to adult bone marrow and white adipose tissue via Pdgfralpha expression. Development 145(2):dev155879 |
| abstractText | Mesenchymal stem cells (MSCs) are somatic stem cells that can be derived from adult bone marrow (BM) and white adipose tissue (WAT), and that display multipotency and self-renewal capacity. Although MSCs are essential for tissue formation and have already been used in clinical therapy, the origins and markers of these cells remain unknown. In this study, we first investigated the developmental process of MSCs in mouse embryos using the gene encoding platelet-derived growth factor receptor alpha (Pdgfra) as a marker. We then traced cells expressing Pdgfra and other genes (brachyury, Sox1 and Pmx1) in various mutant mouse embryos until the adult stage. This tracing of MSC origins and destinies indicates that embryonic MSCs emerge in waves and that almost all adult BM MSCs and WAT MSCs originate from mesoderm and embryonic Pdgfralpha-positive cells. Furthermore, we demonstrate that adult Pdgfralpha-positive cells are involved in some pathological conditions. |
