| First Author | Toyo-oka K | Year | 2014 |
| Journal | J Neurosci | Volume | 34 |
| Issue | 36 | Pages | 12168-81 |
| PubMed ID | 25186760 | Mgi Jnum | J:216299 |
| Mgi Id | MGI:5608618 | Doi | 10.1523/JNEUROSCI.2513-13.2014 |
| Citation | Toyo-oka K, et al. (2014) 14-3-3epsilon and zeta regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain. J Neurosci 34(36):12168-81 |
| abstractText | During brain development, neural progenitor cells proliferate and differentiate into neural precursors. These neural precursors migrate along the radial glial processes and localize at their final destination in the cortex. Numerous reports have revealed that 14-3-3 proteins are involved in many neuronal activities, although their functions in neurogenesis remain unclear. Here, using 14-3-3epsilon/zeta double knock-out mice, we found that 14-3-3 proteins are important for proliferation and differentiation of neural progenitor cells in the cortex, resulting in neuronal migration defects and seizures. 14-3-3 deficiency resulted in the increase of delta-catenin and the decrease of beta-catenin and alphaN-catenin. 14-3-3 proteins regulated neuronal differentiation into neurons via direct interactions with phosphorylated delta-catenin to promote F-actin formation through a catenin/Rho GTPase/Limk1/cofilin signaling pathway. Conversely, neuronal migration defects seen in the double knock-out mice were restored by phosphomimic Ndel1 mutants, but not delta-catenin. Our findings provide new evidence that 14-3-3 proteins play important roles in neurogenesis and neuronal migration via the regulation of distinct signaling cascades. |
