| First Author | Zhang X | Year | 2003 |
| Journal | Genesis | Volume | 35 |
| Issue | 1 | Pages | 22-30 |
| PubMed ID | 12481295 | Mgi Jnum | J:81626 |
| Mgi Id | MGI:2449734 | Doi | 10.1002/gene.10160 |
| Citation | Zhang X, et al. (2003) Cre-loxp fate-mapping of Pax6 enhancer active retinal and pancreatic progenitors. Genesis 35(1):22-30 |
| abstractText | Summary: Pax6 plays important roles in the control of ocular and pancreatic development. We identified a 450 bp Pax6 enhancer that contains two interacting sequences: a 274 bp fragment sufficient for expression in retinal progenitors and an adjacent 156 bp fragment required for expression in pancreatic progenitors. Since this enhancer is only transiently expressed during embryogenesis, a Cre-loxP fate-mapping strategy was used to investigate the developmental potential of these progenitors. Surprisingly, the labeled retinal precursors predominantly gave rise to horizontal cells, indicating a cell lineage role in horizontal cell differentiation. In the pancreas, all enhancer-specific cells were restricted to endocrine and ductal cell lineages. This result lends support to a model whereby Pax6-expressing progenitors contribute to the adult pancreatic islets and ducts. The progenitor cell-specificity of this enhancer will be useful in studies that require either cell-specific expression or conditional gene inactivation in these cell populations. genesis 35:22-30, 2003. |
