| First Author | Hockman D | Year | 2017 |
| Journal | Elife | Volume | 6 |
| PubMed ID | 28387645 | Mgi Jnum | J:260527 |
| Mgi Id | MGI:6142693 | Doi | 10.7554/eLife.21231 |
| Citation | Hockman D, et al. (2017) Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes. Elife 6:e21231 |
| abstractText | The evolutionary origins of the hypoxia-sensitive cells that trigger amniote respiratory reflexes - carotid body glomus cells, and ''pulmonary neuroendocrine cells'' (PNECs) - are obscure. Homology has been proposed between glomus cells, which are neural crest-derived, and the hypoxia-sensitive ''neuroepithelial cells'' (NECs) of fish gills, whose embryonic origin is unknown. NECs have also been likened to PNECs, which differentiate in situ within lung airway epithelia. Using genetic lineage-tracing and neural crest-deficient mutants in zebrafish, and physical fate-mapping in frog and lamprey, we find that NECs are not neural crest-derived, but endoderm-derived, like PNECs, whose endodermal origin we confirm. We discover neural crest-derived catecholaminergic cells associated with zebrafish pharyngeal arch blood vessels, and propose a new model for amniote hypoxia-sensitive cell evolution: endoderm-derived NECs were retained as PNECs, while the carotid body evolved via the aggregation of neural crest-derived catecholaminergic (chromaffin) cells already associated with blood vessels in anamniote pharyngeal arches. |
