| First Author | Schutgens F | Year | 2017 |
| Journal | Proc Natl Acad Sci U S A | Volume | 114 |
| Issue | 52 | Pages | E11190-E11198 |
| PubMed ID | 29237753 | Mgi Jnum | J:255412 |
| Mgi Id | MGI:6107566 | Doi | 10.1073/pnas.1714145115 |
| Citation | Schutgens F, et al. (2017) Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney. Proc Natl Acad Sci U S A 114(52):E11190-E11198 |
| abstractText | During kidney development, progressively committed progenitor cells give rise to the distinct segments of the nephron, the functional unit of the kidney. Similar segment-committed progenitor cells are thought to be involved in the homeostasis of adult kidney. However, markers for most segment-committed progenitor cells remain to be identified. Here, we evaluate Troy/TNFRSF19 as a segment-committed nephron progenitor cell marker. Troy is expressed in the ureteric bud during embryonic development. During postnatal nephrogenesis, Troy(+) cells are present in the cortex and papilla and display an immature tubular phenotype. Tracing of Troy(+) cells during nephrogenesis demonstrates that Troy(+) cells clonally give rise to tubular structures that persist for up to 2 y after induction. Troy(+) cells have a 40-fold higher capacity than Troy(-) cells to form organoids, which is considered a stem cell property in vitro. In the adult kidney, Troy(+) cells are present in the papilla and these cells continue to contribute to collecting duct formation during homeostasis. The number of Troy-derived cells increases after folic acid-induced injury. Our data show that Troy marks a renal stem/progenitor cell population in the developing kidney that in adult kidney contributes to homeostasis, predominantly of the collecting duct, and regeneration. |
