| First Author | Wen J | Year | 2013 |
| Journal | PLoS One | Volume | 8 |
| Issue | 5 | Pages | e64451 |
| PubMed ID | 23691221 | Mgi Jnum | J:221023 |
| Mgi Id | MGI:5637658 | Doi | 10.1371/journal.pone.0064451 |
| Citation | Wen J, et al. (2013) beta-Catenin is critical for cerebellar foliation and lamination. PLoS One 8(5):e64451 |
| abstractText | The cerebellum has a conserved foliation pattern and a well-organized layered structure. The process of foliation and lamination begins around birth. beta-catenin is a downstream molecule of Wnt signaling pathway, which plays a critical role in tissue organization. Lack of beta-catenin at early embryonic stages leads to either prenatal or neonatal death, therefore it has been difficult to resolve its role in cerebellar foliation and lamination. Here we used GFAP-Cre to ablate beta-catenin in neuronal cells of the cerebellum after embryonic day 12.5, and found an unexpected role of beta-catenin in determination of the foliation pattern. In the mutant mice, the positions of fissure formation were changed, and the meninges were improperly incorporated into fissures. At later stages, some lobules were formed by Purkinje cells remaining in deep regions of the cerebellum and the laminar structure was dramatically altered. Our results suggest that beta-catenin is critical for cerebellar foliation and lamination. We also found a non cell-autonomous role of beta-catenin in some developmental properties of major cerebellar cell types during specific stages. |
