| First Author | Stubbusch J | Year | 2011 |
| Journal | Genesis | Volume | 49 |
| Issue | 12 | Pages | 935-41 |
| PubMed ID | 21634003 | Mgi Jnum | J:180731 |
| Mgi Id | MGI:5306909 | Doi | 10.1002/dvg.20773 |
| Citation | Stubbusch J, et al. (2011) Generation of the tamoxifen-inducible DBH-Cre transgenic mouse line DBH-CT. Genesis 49(12):935-41 |
| abstractText | We generated transgenic mice bearing a tamoxifen-dependent Cre recombinase expressed under the control of the dopamine-beta-hydroxylase promoter. By crossing to the ROSA26 reporter mice we show that tamoxifen-induced Cre recombinase in adult mice specifically activates beta-galactosidase expression in differentiated noradrenergic neurons of the central and peripheral nervous system. Tamoxifen application in adult mice did not induce beta-galactosidase activity in parasympathetic neurons that transiently express DBH during development. Thus, this transgenic mouse line represents a valuable tool to study gene function in mature noradrenergic neurons by conditional inactivation. |
