| First Author | Otipoby KL | Year | 2015 |
| Journal | Proc Natl Acad Sci U S A | Volume | 112 |
| Issue | 39 | Pages | 12145-50 |
| PubMed ID | 26371314 | Mgi Jnum | J:227001 |
| Mgi Id | MGI:5699501 | Doi | 10.1073/pnas.1516428112 |
| Citation | Otipoby KL, et al. (2015) The B-cell antigen receptor integrates adaptive and innate immune signals. Proc Natl Acad Sci U S A 112(39):12145-50 |
| abstractText | B cells respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or pathogen-associated molecular patterns are delivered. We show that the proliferative response of B cells to the latter stimuli is controlled by BCR-dependent activation of phosphoinositidyl 3-kinase (PI-3K) signaling. Glycogen synthase kinase 3beta and Foxo1 are two PI-3K-regulated targets that play important roles, but to different extents, depending on the specific mitogen. These results suggest a model for integrating signals from the innate and the adaptive immune systems in the control of the B-cell immune response. |
