| First Author | García-Ojeda ME | Year | 2013 |
| Journal | Blood | Volume | 121 |
| Issue | 10 | Pages | 1749-59 |
| PubMed ID | 23287858 | Mgi Jnum | J:194772 |
| Mgi Id | MGI:5474718 | Doi | 10.1182/blood-2012-06-440065 |
| Citation | Garcia-Ojeda ME, et al. (2013) GATA-3 promotes T-cell specification by repressing B-cell potential in pro-T cells in mice. Blood 121(10):1749-59 |
| abstractText | Transcription factors orchestrate T-lineage differentiation in the thymus. One critical checkpoint involves Notch1 signaling that instructs T-cell commitment at the expense of the B-lineage program. While GATA-3 is required for T-cell specification, its mechanism of action is poorly understood. We show that GATA-3 works in concert with Notch1 to commit thymic progenitors to the T-cell lineage via 2 distinct pathways. First, GATA-3 orchestrates a transcriptional "repertoire" that is required for thymocyte maturation up to and beyond the pro-T-cell stage. Second, GATA-3 critically suppresses a latent B-cell potential in pro-T cells. As such, GATA-3 is essential to sealing in Notch-induced T-cell fate in early thymocyte precursors by promoting T-cell identity through the repression of alternative developmental options. |
