| First Author | Apostolopoulos V | Year | 2000 |
| Journal | Eur J Immunol | Volume | 30 |
| Issue | 6 | Pages | 1733-9 |
| PubMed ID | 10898511 | Mgi Jnum | J:62734 |
| Mgi Id | MGI:1859504 | Doi | 10.1002/1521-4141(200006)30:6<1733::AID-IMMU1733>3.0.CO;2-E |
| Citation | Apostolopoulos V, et al. (2000) A role for IL-5 in the induction of cytotoxic T lymphocytes in vivo. Eur J Immunol 30(6):1733-9 |
| abstractText | IL-5 is generally regarded as a Th2 cytokine involved in eosinophil maturation and function and in B cell growth and antibody production, but without any well-established effects on T cells. Early reports suggested that IL-5 could stimulate the production of cytotoxic T lymphocytes (CTL) in vitro, but no evidence has been obtained to date for such a role in studies with IL-5-deficient (IL-5-/-) mice. Here we demonstrate that when oxidized mannan MUC1 fusion protein (M-FP) is used as an antigen in mice, IL-5 is required for the optimal generation of the CTL response. IL-5 was as effective as IL-2 for the induction of CTL from spleen cells in vitro and both CD4+ and CD8+ T cells from M-FP-immunized animals could be shown to secrete IL-5 in culture. In IL-5-/- mice, CTLp frequency was greatly diminished resulting in the inability to reject MUC1- tumors. Clearly, IL-5 is produced by functional T cells, especially the Tc1 type, after M-FP immunization and is required for an optimal CTL response to this antigen. |
