| First Author | Urrea L | Year | 2018 |
| Journal | Mol Neurobiol | Volume | 55 |
| Issue | 3 | Pages | 1847-1860 |
| PubMed ID | 28229331 | Mgi Jnum | J:339481 |
| Mgi Id | MGI:7522620 | Doi | 10.1007/s12035-017-0451-4 |
| Citation | Urrea L, et al. (2018) Involvement of Cellular Prion Protein in alpha-Synuclein Transport in Neurons. Mol Neurobiol 55(3):1847-1860 |
| abstractText | The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of beta-amyloid. Their interaction is mandatory for neurotoxic effects of beta-amyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of alpha-synuclein. Results demonstrate that Prnp expression is not mandatory for alpha-synuclein spreading. However, although the pathological spreading of alpha-synuclein can take place in the absence of Prnp, alpha-synuclein expanded faster in PrP(C)-overexpressing mice. In addition, alpha-synuclein binds strongly on PrP(C)-expressing cells, suggesting a role in modulating the effect of alpha-synuclein fibrils. |
