| First Author | Young R | Year | 2009 |
| Journal | FEBS Lett | Volume | 583 |
| Issue | 19 | Pages | 3296-300 |
| PubMed ID | 19766638 | Mgi Jnum | J:153761 |
| Mgi Id | MGI:4366204 | Doi | 10.1016/j.febslet.2009.09.027 |
| Citation | Young R, et al. (2009) The prion or the related Shadoo protein is required for early mouse embryogenesis. FEBS Lett 583(19):3296-300 |
| abstractText | The prion protein PrP has a key role in transmissible spongiform encephalopathies but its biological function remains largely unknown. Recently, a related protein, Shadoo, was discovered. Its biological properties and brain distribution partially overlap that of PrP. We report that the Shadoo-encoding gene knockdown in PrP-knockout mouse embryos results in a lethal phenotype, occurring between E8 and E11, not observed on the wild-type genetic background. It reveals that these two proteins play a shared, crucial role in mammalian embryogenesis, explaining the lack of severe phenotype in PrP-knockout mammals, an appreciable step towards deciphering the biological role of this protein family. |
