| First Author | Kubosaki A | Year | 2003 |
| Journal | Biochem Biophys Res Commun | Volume | 307 |
| Issue | 4 | Pages | 810-3 |
| PubMed ID | 12878182 | Mgi Jnum | J:113587 |
| Mgi Id | MGI:3687066 | Doi | 10.1016/s0006-291x(03)01263-4 |
| Citation | Kubosaki A, et al. (2003) Expression of normal cellular prion protein (PrP(c)) on T lymphocytes and the effect of copper ion: Analysis by wild-type and prion protein gene-deficient mice. Biochem Biophys Res Commun 307(4):810-3 |
| abstractText | The purpose of this report was to determine the effect of prion protein (PrP) gene disruption on T lymphocyte function. Previous studies have suggested that normal cellular prion protein (PrP(c)) binds to copper and Cu(2+) is essential for interleukin-2 (IL-2) mRNA synthesis. In this study, IL-2 mRNA levels in a copper-deficient condition were investigated using T lymphocytes from prion protein gene-deficient (PrP(0/0)) and wild-type mice. Results showed that Cu(2+) deficiency had no effect on PrP(c) expression in Con A-activated splenocytes. However, a delay in IL-2 gene expression was observed in PrP(0/0) mouse T lymphocyte cultures using Con A and Cu(2+)-chelator. These results suggest that PrP(c) expression may play an important role in rapid Cu(2+) transfer in T lymphocytes. The rapid transfer of Cu(2+) in murine T lymphocytes could be one of the normal functions of PrP(c). |
