| First Author | Gains MJ | Year | 2006 |
| Journal | Neuroreport | Volume | 17 |
| Issue | 9 | Pages | 903-6 |
| PubMed ID | 16738485 | Mgi Jnum | J:110126 |
| Mgi Id | MGI:3639393 | Doi | 10.1097/01.wnr.0000220144.14166.e2 |
| Citation | Gains MJ, et al. (2006) Prion protein protects against ethanol-induced Bax-mediated cell death in vivo. Neuroreport 17(9):903-6 |
| abstractText | Prion protein inhibits Bax activation and Bax-mediated cell death in primary cultures of human neurons and in MCF-7 cells. To determine whether prion protein can protect against Bax-mediated cell death in vivo, wild-type, null and prion over-expressing mice were subjected to Bax-dependent ethanol induced neuronal apoptotic cell death and the brains were immunostained for active caspase-3 as a downstream marker of Bax activation. Bax activation occurs in all ethanol-injected mice independent of their genotype. A higher level of cell death is present in ethanol-injected null mice than in wild-type and prion over-expressing mice. We conclude that prion protein protects some, but not all neurons, against Bax-mediated cell death in this experimental paradigm. |
