| First Author | Young R | Year | 2011 |
| Journal | Biochem Biophys Res Commun | Volume | 416 |
| Issue | 1-2 | Pages | 184-7 |
| PubMed ID | 22093825 | Mgi Jnum | J:179204 |
| Mgi Id | MGI:5301458 | Doi | 10.1016/j.bbrc.2011.11.021 |
| Citation | Young R, et al. (2011) Expression of the prion-like protein Shadoo in the developing mouse embryo. Biochem Biophys Res Commun 416(1-2):184-7 |
| abstractText | The prion-like protein Shadoo has been suggested to compensate for the lack of PrP in Prnp-knockout mice, explaining their lack of extreme phenotype. In adult mice, both PrP and Shadoo have shown overlapping expression patterns and shared functions [1]. Their expression in the mouse embryo has also been suggested to be complementary, as invalidation of both genes results in embryonic lethality [2]. The developmental expression profile of PrP has been described from post-implantation stages up until birth [3-5]. However the spatial expression pattern of Shadoo in the developing mouse embryo is not known. We previously described the expression profile of the prion-like protein Shadoo in adult mice using Sprn reporter mice (Sprn-GFP and Sprn-LacZ). Here we used these mice to describe the developmental expression of Shadoo between 10.5 and 14.5dpc. The observed pattern in specific embryonic cell lineages and in extra-embryonic tissues is consistent with the previously reported phenotype resulting from its knockdown. |
