| First Author | Hartmann CA | Year | 2013 |
| Journal | FEBS Lett | Volume | 587 |
| Issue | 2 | Pages | 238-44 |
| PubMed ID | 23238082 | Mgi Jnum | J:192540 |
| Mgi Id | MGI:5465356 | Doi | 10.1016/j.febslet.2012.11.032 |
| Citation | Hartmann CA, et al. (2013) High levels of cellular prion protein improve astrocyte development. FEBS Lett 587(2):238-44 |
| abstractText | Prion protein (PrP(C)) has neuroprotective functions and herein we demonstrate that astrocytes from PrP(C)-over-expressing mice are more resistant to induced cell death than wild-type astrocytes. The Stress-Inducible-Protein 1 (STI1), a PrP(C) ligand, prevents cell death in both wild-type and PrP(C)-over-expressing astrocytes through the activation of protein-kinase-A. Cultured embryonic astrocytes and brain extracts from PrP(C)-over-expressing mice show higher glial fibrillary acidic protein expression and reduced vimentin and nestin levels when compared to wild-type astrocytes, suggesting faster astrocyte maturation in the former mice. Our data indicate that PrP(C) levels modulate astrocyte development, and that PrP(C)-STI1 interaction contributes to protect against astrocyte death. |
