| First Author | Mata X | Year | 2003 |
| Journal | FEBS Lett | Volume | 549 |
| Issue | 1-3 | Pages | 163-6 |
| PubMed ID | 12914944 | Mgi Jnum | J:129158 |
| Mgi Id | MGI:3768750 | Doi | 10.1016/s0014-5793(03)00806-8 |
| Citation | Mata X, et al. (2003) Unexpected high testis-specific transcriptional activity of the cyclin T1 promoter in transgenic mice. FEBS Lett 549(1-3):163-6 |
| abstractText | The ubiquitously expressed cyclin T1 gene encodes for a protein involved in human immunodeficiency virus type 1 (HIV-1) transcription activation. The goat gene was recently shown to share an expression pattern similar to that of its endogenous counterpart when incorporated into mice using a BAC insert. To assess if its promoter could target ubiquitous expression of the bovine Prnp in transgenic mice, two constructs carrying either 1 or 30 kb of cyclin T1 5'-flanking sequences were built and microinjected. Both constructs resulted in the unexpected high male germ cell-specific expression of the prion protein. These data re-question the suspected location of the cyclin T1 gene regulatory elements. |
