| First Author | Wang J | Year | 2005 |
| Journal | J Biol Chem | Volume | 280 |
| Issue | 45 | Pages | 37725-31 |
| PubMed ID | 16155000 | Mgi Jnum | J:102895 |
| Mgi Id | MGI:3608208 | Doi | 10.1074/jbc.M507976200 |
| Citation | Wang J, et al. (2005) Glucocorticoid-induced tumor necrosis factor receptor is a p21Cip1/WAF1 transcriptional target conferring resistance of keratinocytes to UV light-induced apoptosis. J Biol Chem 280(45):37725-31 |
| abstractText | Glucocorticoid-induced tumor necrosis factor receptor (GITR) is a member of the tumor necrosis factor receptor superfamily, is expressed in T lymphocytes, and exerts an anti-apoptotic function in these cells. We reported that GITR is also highly expressed in the skin, specifically in keratinocytes, and that it is under negative transcriptional control of p21(Cip1/WAF1), independently from the cell cycle. Although GITR expression is higher in p21-deficient keratinocytes and skin, it is down-modulated with differentiation and in response to UVB. The combined analysis of keratinocytes with increased GITR expression versus normal keratinocytes and skin of mice with a disruption of the GITR gene indicates that this protein protects keratinocytes from UVB-induced apoptosis both in vitro and in vivo. |
