| First Author | Kan Q | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 30 | Pages | 5879-84 |
| PubMed ID | 18067863 | Mgi Jnum | J:130331 |
| Mgi Id | MGI:3771489 | Doi | 10.1016/j.febslet.2007.11.075 |
| Citation | Kan Q, et al. (2007) Chemical DNA damage activates p21 WAF1/CIP1-dependent intra-S checkpoint. FEBS Lett 581(30):5879-84 |
| abstractText | When cells progressing in G(1) phase are irradiated with UV light, two damage checkpoint pathways are activated: CHK1-Cdc25A and p53-p21WAF1/CIP1, both targeting Cdk2 but the latter inducing long lasting inactivation. In similarly irradiated S phase cells, however, p21WAF1/CIP1-dependent checkpoint is largely inactive. We report here that p21-dependent checkpoint can effectively be activated and induce a prolonged S phase arrest with similarly extended inactivation of Cdk2 by association of p21 if mid-S phase cells are damaged with a base-modifying agent instead of UV light, indicating that the poor utilization of p21-dependent checkpoint is not an innate property of S phase cells. |
