| First Author | Meyer EL | Year | 2008 |
| Journal | J Neurochem | Volume | 105 |
| Issue | 5 | Pages | 1761-9 |
| PubMed ID | 18248619 | Mgi Jnum | J:135344 |
| Mgi Id | MGI:3793406 | Doi | 10.1111/j.1471-4159.2008.05266.x |
| Citation | Meyer EL, et al. (2008) The neuronal nicotinic acetylcholine receptors alpha4* and alpha6* differentially modulate dopamine release in mouse striatal slices. J Neurochem 105(5):1761-9 |
| abstractText | Striatal dopamine (DA) plays a major role in the regulation of motor coordination and in the processing of salient information. We used voltammetry to monitor DA-release evoked by electrical stimulation in striatal slices, where interneurons continuously release acetylcholine. Use of the alpha6-selective antagonist alpha-conotoxin MII[E11A] and alpha4 knockout mice enabled identification of two populations of DA-ergic fibers. The first population had a low action potential threshold, and action potential-evoked DA-release from these fibers was modulated by alpha6. The second population had a higher action potential threshold, and only alpha4(non-alpha6) modulated action potential-evoked DA-release. Striatal DA-ergic neurons fire in both tonic and phasic patterns. When stimuli were applied in a train to mimic phasic firing, more DA-release was observed in alpha4 knockout versus wild-type mice. Furthermore, block of alpha4(non-alpha6), but not of alpha6, increased DA release evoked by a train. These results indicate that there are different classes of striatal DA-ergic fibers that express different subtypes of nicotinic receptors. |
