| First Author | Nepomnaschy I | Year | 2000 |
| Journal | Scand J Immunol | Volume | 52 |
| Issue | 6 | Pages | 555-62 |
| PubMed ID | 11119260 | Mgi Jnum | J:103940 |
| Mgi Id | MGI:3610895 | Doi | 10.1046/j.1365-3083.2000.00818.x |
| Citation | Nepomnaschy I, et al. (2000) Alterations during positive selection in the thymus of nackt CD4-deficient mice. Scand J Immunol 52(6):555-62 |
| abstractText | The T-cell repertoire is shaped by the positive and negative selection of immature CD4(+) CD8(+) double positive (DP) thymocytes. Positive selection of DP T cells to the CD4(+) CD8(-) and CD4(-) CD8(+) simple positive (SP) lineages is a multistep process which involves cellular interactions between thymocytes and stromal cells. Mutant nackt (nkt/nkt) mice have been shown to have a deficiency in the CD4(+) CD8(-) T-cell subset both in the thymus and in the periphery. The present report suggests that nkt/nkt mice present alterations in early steps of positive selection because they show decreases in the percentages of CD69(+) and CD5(+) cells within the DP subset. Experiments involving bone marrow transfer and thymic chimeras demonstrate that the thymic epithelium of nkt/nkt mice is involved in the alterations registered during positive selection and dictates the ultimate fate of CD4(+) SP cells. |
