Other
12 Authors
- Plouffe SW,
- Guan KL,
- Park HW,
- Moroishi T,
- Wang CY,
- Kim YC,
- Meng Z,
- Yu FX,
- Yu B,
- Mo JS,
- Lin KC,
- Alexander CM
| First Author | Park HW | Year | 2015 |
| Journal | Cell | Volume | 162 |
| Issue | 4 | Pages | 780-94 |
| PubMed ID | 26276632 | Mgi Jnum | J:224825 |
| Mgi Id | MGI:5689180 | Doi | 10.1016/j.cell.2015.07.013 |
| Citation | Park HW, et al. (2015) Alternative Wnt Signaling Activates YAP/TAZ. Cell 162(4):780-94 |
| abstractText | The transcriptional co-activators YAP and TAZ are key regulators of organ size and tissue homeostasis, and their dysregulation contributes to human cancer. Here, we discover YAP/TAZ as bona fide downstream effectors of the alternative Wnt signaling pathway. Wnt5a/b and Wnt3a induce YAP/TAZ activation independent of canonical Wnt/beta-catenin signaling. Mechanistically, we delineate the "alternative Wnt-YAP/TAZ signaling axis" that consists of Wnt-FZD/ROR-Galpha12/13-Rho GTPases-Lats1/2 to promote YAP/TAZ activation and TEAD-mediated transcription. YAP/TAZ mediate the biological functions of alternative Wnt signaling, including gene expression, osteogenic differentiation, cell migration, and antagonism of Wnt/beta-catenin signaling. Together, our work establishes YAP/TAZ as critical mediators of alternative Wnt signaling. |
