| First Author | Rossi O | Year | 2019 |
| Journal | Immunology | Volume | 156 |
| Issue | 1 | Pages | 69-73 |
| PubMed ID | 30179254 | Mgi Jnum | J:269331 |
| Mgi Id | MGI:6259945 | Doi | 10.1111/imm.13000 |
| Citation | Rossi O, et al. (2019) The essential role of complement in antibody-mediated resistance to Salmonella. Immunology 156(1):69-73 |
| abstractText | Vaccines can serve as essential tools to prevent bacterial diseases via the induction of long-lasting IgG responses. The efficacy of such vaccines depends on the effector mechanisms triggered by IgG. The complement system and Fc-gamma receptors (FcgammaRs) can potentially play a crucial role in IgG-mediated immunity against bacterial diseases. However, their relative importance in vivo is unclear, and has been the object of controversy and debate. In this brief study, we have used gene-targeted mice lacking either FcgammaRI, II, II and IV or the C3 complement component as well as a novel mouse strain lacking both C3 and FcgammaRs to conclusively show the essential role of complement in antibody-mediated host resistance to Salmonella enterica systemic infection. By comparing the effect of IgG2a antibodies against Salmonella O-antigen in gene-targeted mice, we demonstrate that the complement system is essential for the IgG-mediated reduction of bacterial numbers in the tissues. |
