| First Author | Kopf M | Year | 2002 |
| Journal | Nat Med | Volume | 8 |
| Issue | 4 | Pages | 373-8 |
| PubMed ID | 11927943 | Mgi Jnum | J:126202 |
| Mgi Id | MGI:3760705 | Doi | 10.1038/nm0402-373 |
| Citation | Kopf M, et al. (2002) Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection. Nat Med 8(4):373-8 |
| abstractText | The complement cascade defines an important link between the innate and the specific immune system. Here we show that mice deficient for the third component of complement (C3-/- mice) are highly susceptible to primary infection with influenza virus. C3-/- mice showed delayed viral clearance and increased viral titers in lung, whereas mice deficient for complement receptors CR1 and CR2 (Cr2-/- mice) cleared the infection normally. Priming of T-helper cells and cytotoxic T cells (CTLs) in lung-draining lymph nodes was reduced, and the recruitment into the lung of virus-specific CD4+ and CD8+ effector T cells producing interferon-gamma was severely impaired in C3-/- but not in Cr2-/- mice. Consequently, T-helper cell-dependent IgG responses were reduced in C3-/- mice but remained intact in Cr2-/- mice. These results demonstrate that complement induces specific immunity by promoting T-cell responses. |
