| First Author | Freeman GJ | Year | 1993 |
| Journal | Science | Volume | 262 |
| Issue | 5135 | Pages | 907-9 |
| PubMed ID | 7694362 | Mgi Jnum | J:74662 |
| Mgi Id | MGI:2158941 | Doi | 10.1126/science.7694362 |
| Citation | Freeman GJ, et al. (1993) Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science 262(5135):907-9 |
| abstractText | B7 delivers a costimulatory signal through CD28, resulting in interleukin-2 secretion and T cell proliferation. Blockade of this pathway results in T cell anergy. The in vivo role of B7 was evaluated with B7-deficient mice. These mice had a 70 percent decrease in costimulation of the response to alloantigen. Despite lacking B7 expression, activated B cells from these mice bound CTLA-4 and GL1 monoclonal antibody, demonstrating that alternative CTLA-4 ligand or ligands exist. These receptors are functionally important because the residual allogenic mixed lymphocyte responses were blocked by CTLA4Ig. Characterization of these CTLA-4 ligands should lead to strategies for manipulating the immune response. |
