| First Author | Garcia-Reitboeck P | Year | 2013 |
| Journal | Exp Neurol | Volume | 248 |
| Pages | 541-5 | PubMed ID | 23933574 |
| Mgi Jnum | J:203866 | Mgi Id | MGI:5528943 |
| Doi | 10.1016/j.expneurol.2013.07.015 | Citation | Garcia-Reitboeck P, et al. (2013) Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra. Exp Neurol 248:541-5 |
| abstractText | The presynaptic protein alpha-synuclein is central to the pathogenesis of alpha-synucleinopathies. We show that the presence of endogenous mouse alpha-synuclein leads to higher number of dopaminergic neurons in the substantia nigra of wild-type C57Bl/6J mice compared with C57Bl/6S mice with a spontaneous deletion of the alpha-synuclein gene or C57Bl/6J mice with a targeted deletion of the alpha-synuclein gene. This effect of alpha-synuclein on dopaminergic neuron occurs during development between E10.5 and E13.5 and persists in adult life supporting the involvement of alpha-synuclein in the development of a subset of dopaminergic neurons. |
