| First Author | Taguchi K | Year | 2020 |
| Journal | Mol Neurobiol | Volume | 57 |
| Issue | 3 | Pages | 1291-1304 |
| PubMed ID | 31722091 | Mgi Jnum | J:302191 |
| Mgi Id | MGI:6507646 | Doi | 10.1007/s12035-019-01814-3 |
| Citation | Taguchi K, et al. (2020) alpha-Synuclein Promotes Maturation of Immature Juxtaglomerular Neurons in the Mouse Olfactory Bulb. Mol Neurobiol 57(3):1291-1304 |
| abstractText | alpha-Synuclein (alphaSyn), the major constituent of Lewy bodies and Lewy neurites, is generally expressed in presynapses and is involved in synaptic function. However, we previously demonstrated that some neurons, including those in the olfactory bulb, show high alphaSyn expression levels in the cell body under normal conditions. alphaSyn is also known to be important for adult neurogenesis. Thus, in present study, we examined the role of alphaSyn in juxtaglomerular neurons (JGNs) with high alphaSyn expression in the mouse olfactory bulb. Most alphaSyn-enriched JGNs expressed sex-determining region Y-box 2 (Sox2), which functions to maintain neural immature identity. Interestingly, in alphaSyn homozygous (-/-) knockout (KO) mice, Sox2-positive JGNs were significantly increased compared with heterozygous (+/-) KO mice. Following global brain ischemia using wild-type mice, there was also a significant decrease in Sox2-positive JGNs, and in the co-expression ratio of Sox2 in alphaSyn-enriched JGNs. By contrast, the co-expression ratio of neuronal nuclei (NeuN, mature neuronal marker) was significantly increased in alphaSyn-enriched JGNs. However, this ischemia-induced decrease of Sox2-positive JGNs was not observed in alphaSyn homozygous KO mice. Overall, these data suggest that alphaSyn functions to promote the maturation of immature JGNs in the mouse olfactory bulb. |
