| First Author | Somayaji M | Year | 2020 |
| Journal | Proc Natl Acad Sci U S A | Volume | 117 |
| Issue | 51 | Pages | 32701-32710 |
| PubMed ID | 33273122 | Mgi Jnum | J:300944 |
| Mgi Id | MGI:6492031 | Doi | 10.1073/pnas.2013652117 |
| Citation | Somayaji M, et al. (2020) A dual role for alpha-synuclein in facilitation and depression of dopamine release from substantia nigra neurons in vivo. Proc Natl Acad Sci U S A 117(51):32701-32710 |
| abstractText | alpha-Synuclein is expressed at high levels at presynaptic terminals, but defining its role in the regulation of neurotransmission under physiologically relevant conditions has proven elusive. We report that, in vivo, alpha-synuclein is responsible for the facilitation of dopamine release triggered by action potential bursts separated by short intervals (seconds) and a depression of release with longer intervals between bursts (minutes). These forms of presynaptic plasticity appear to be independent of the presence of beta- and gamma-synucleins or effects on presynaptic calcium and are consistent with a role for synucleins in the enhancement of synaptic vesicle fusion and turnover. These results indicate that the presynaptic effects of alpha-synuclein depend on specific patterns of neuronal activity. |
